Dormant and self-renewing hematopoietic stem cells and their niches.

Details

Serval ID
serval:BIB_1FA10D47AD11
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Dormant and self-renewing hematopoietic stem cells and their niches.
Journal
Annals of the New York Academy of Sciences
Author(s)
Wilson A., Oser G.M., Jaworski M., Blanco-Bose W.E., Laurenti E., Adolphe C., Essers M.A., Macdonald H.R., Trumpp A.
ISSN
0077-8923
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
1106
Pages
64-75
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
In the mouse, over the last 20 years, a set of cell-surface markers and activities have been identified, enabling the isolation of bone marrow (BM) populations highly enriched in hematopoietic stem cells (HSCs). These HSCs have the ability to generate multiple lineages and are capable of long-term self-renewal activity such that they are able to reconstitute and maintain a functional hematopoietic system after transplantation into lethally irradiated recipients. Using single-cell reconstitution assays, various marker combinations can be used to achieve a functional HSC purity of almost 50%. Here we have used the differential expression of six of these markers (Sca1, c-Kit, CD135, CD48, CD150, and CD34) on lineage-depleted BM to refine cell hierarchies within the HSC population. At the top of the hierarchy, we propose a dormant HSC population (Lin(-)Sca1(+)c-Kit(+) CD48(-)CD150(+)CD34(-)) that gives rise to an active self-renewing CD34(+) HSC population. HSC dormancy, as well as the balance between self-renewal and differentiation activity, is at least, in part, controlled by the stem cell niches individual HSCs are attached to. Here we review the current knowledge about HSC niches and propose that dormant HSCs are located in niches at the endosteum, whereas activated HSCs are in close contact to sinusoids of the BM microvasculature.
Keywords
Animals, Bone Marrow/metabolism, Bone Marrow Cells/cytology, Cell Differentiation, Gene Expression Regulation, Hematopoietic Stem Cells/cytology, Mice, Models, Biological, Models, Genetic, Osteoblasts/metabolism, Phenotype
Pubmed
Web of science
Create date
09/02/2010 14:06
Last modification date
20/08/2019 12:55
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