Targeting the JNK pathway as a therapeutic protective strategy for nervous system diseases

Details

Serval ID
serval:BIB_1BFEF7DDACD8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Targeting the JNK pathway as a therapeutic protective strategy for nervous system diseases
Journal
Reviews in the Neurosciences
Author(s)
Bonny  C., Borsello  T., Zine  A.
ISSN
0334-1763 (Print)
Publication state
Published
Issued date
2005
Volume
16
Number
1
Pages
57-67
Notes
Journal Article
Review
Abstract
The c-Jun N-terminal kinases (JNKs) are members of the family of mitogen activated protein kinases (MAPKs). While the functions of the JNKs under physiological conditions are diverse and not completely understood, there is increasing evidence that JNKs are potent effectors of apoptosis in both the brain and the mammalian inner ear following a variety of injuries. The activation of the inducible transcription factor c-Jun by N-terminal phosphorylation is a central event in JNK-mediated neural and inner ear hair cell death. A cell permeable peptide designed specifically to inhibit JNK signaling has proven successful in in vivo models of both neuronal degeneration following cerebral ischemia and auditory hair cell degeneration following exposure to either acoustic trauma or a toxic level of an aminoglycoside antibiotic. Here we discuss the evidence supporting the application of JNK inhibitors to prevent cellular degeneration in several central nervous system (CNS) and peripheral nervous system (PNS) diseases with an emphasis on traumatic ischemic damage to the CNS and acquired deafness in the PNS receptors.
Keywords
Animals Brain Ischemia/drug therapy/enzymology/physiopathology Deafness/drug therapy/enzymology/physiopathology Hair Cells/drug effects/enzymology/physiopathology Humans JNK Mitogen-Activated Protein Kinases/drug effects/*metabolism Nerve Degeneration/*drug therapy/*enzymology/prevention & control Nervous System Diseases/*drug therapy/*enzymology/physiopathology Neuroprotective Agents/chemistry/*pharmacology Neurotoxicity Syndromes/drug therapy/enzymology/physiopathology Signal Transduction/drug effects/physiology
Pubmed
Web of science
Create date
24/01/2008 14:20
Last modification date
20/08/2019 12:52
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