Biocompatibility of an x-shaped zirconium implant in deep sclerectomy in rabbits.

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Serval ID
serval:BIB_1B9C76BCC985
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Biocompatibility of an x-shaped zirconium implant in deep sclerectomy in rabbits.
Journal
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie
Author(s)
Basso A., Roy S., Mermoud A.
ISSN
0721-832X
Publication state
Published
Issued date
2008
Volume
246
Number
6
Pages
849-855
Language
english
Abstract
BACKGROUND: The aim of this study was to evaluate the mid-term biocompatibility of a new x-shaped implant made of zirconium in an animal model of glaucoma surgery. METHODS: Preoperatively, ultrasound biomicroscopy (UBM), intraocular pressure (IOP) and outflow facility (OF) data were acquired. Upon surgery, one eye was chosen randomly to receive an implant, while the other received none. Ten rabbits went through a 1-, 2-, 3-, 4- and 6-month follow-up. IOP was measured regularly, UBM performed at 1, 3 and 6 months after surgery. At the end of the follow-up, OF was again measured. Histology sections were analyzed. RESULTS: For both groups IOP control was satisfactory, while OF initially increased at month 1 to resume preoperative values thereafter. Eyes with implants had larger filtration blebs which decreased faster than in eyes without the implant. Drainage vessel density, inflammatory cell number and fibrosis were higher in tissues near the implant. CONCLUSIONS: The zirconium implant initially promoted the positive effects of the surgery (IOP control, OF increase). Nevertheless, after several months, foreign body reactions and fibrosis had occurred on some implants that restrained the early benefit of such a procedure. Modifications of the zirconium implant geometry could enhance the overall success rate.
Keywords
Animals, Aqueous Humor, Biocompatible Materials, Glaucoma Drainage Implants, Glaucoma, Open-Angle, Intraocular Pressure, Materials Testing, Microscopy, Acoustic, Models, Animal, Rabbits, Sclera, Sclerostomy, Tonometry, Ocular, Zirconium
Pubmed
Web of science
Open Access
Yes
Create date
22/01/2009 14:48
Last modification date
14/02/2022 7:54
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