Invasive carcinoma arising from a colonic adenoma with clear cell change.

Details

Serval ID
serval:BIB_1AB22D982981
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Invasive carcinoma arising from a colonic adenoma with clear cell change.
Journal
Human Pathology
Author(s)
Pusztaszeri M., Bouzourene H.
ISSN
1532-8392[electronic]
Publication state
Published
Issued date
2008
Volume
39
Number
9
Pages
1402-1405
Language
english
Notes
Publication types: Case Reports ; Journal Article
Abstract
Clear cell change (CCC) in colonic adenoma is rare, and its biological and clinical significance remains unknown. Malignant progression of an adenoma with CCC has seldom been reported. We report a case of a sigmoid adenoma with multiple foci of CCC associated with high-grade dysplasia and invasive carcinoma in a 62-year-old patient. We evaluated the histochemical and immunohistochemical characteristics of each component of the adenoma. In contrast to other parts of the adenoma, p53 was strongly and diffusely overexpressed in the areas of CCC, high-grade dysplasia, and carcinoma. The MIB-1 labeling index was also significantly higher in these components than in other parts of the adenoma. In conclusion, our findings suggest that CCC in adenoma may be associated with malignant progression of the adenoma. Hence, for practical purposes, we recommend considering CCC in colonic adenomas as a high-grade dysplasia equivalent and following up the patient accordingly.
Keywords
Adenoma, Carcinoembryonic Antigen, Humans, Male, Middle Aged, Neoplasm Invasiveness, Sigmoid Neoplasms, Tumor Suppressor Protein p53
Pubmed
Web of science
Create date
07/08/2008 10:03
Last modification date
20/08/2019 12:51
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