Invasive carcinoma arising from a colonic adenoma with clear cell change.

Détails

ID Serval
serval:BIB_1AB22D982981
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Invasive carcinoma arising from a colonic adenoma with clear cell change.
Périodique
Human Pathology
Auteur(s)
Pusztaszeri M., Bouzourene H.
ISSN
1532-8392[electronic]
Statut éditorial
Publié
Date de publication
2008
Volume
39
Numéro
9
Pages
1402-1405
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Résumé
Clear cell change (CCC) in colonic adenoma is rare, and its biological and clinical significance remains unknown. Malignant progression of an adenoma with CCC has seldom been reported. We report a case of a sigmoid adenoma with multiple foci of CCC associated with high-grade dysplasia and invasive carcinoma in a 62-year-old patient. We evaluated the histochemical and immunohistochemical characteristics of each component of the adenoma. In contrast to other parts of the adenoma, p53 was strongly and diffusely overexpressed in the areas of CCC, high-grade dysplasia, and carcinoma. The MIB-1 labeling index was also significantly higher in these components than in other parts of the adenoma. In conclusion, our findings suggest that CCC in adenoma may be associated with malignant progression of the adenoma. Hence, for practical purposes, we recommend considering CCC in colonic adenomas as a high-grade dysplasia equivalent and following up the patient accordingly.
Mots-clé
Adenoma, Carcinoembryonic Antigen, Humans, Male, Middle Aged, Neoplasm Invasiveness, Sigmoid Neoplasms, Tumor Suppressor Protein p53
Pubmed
Web of science
Création de la notice
07/08/2008 10:03
Dernière modification de la notice
20/08/2019 12:51
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