Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.
Details
Download: BIB_1A1C34CA4648.P001.pdf (352.26 [Ko])
State: Public
Version: author
State: Public
Version: author
Serval ID
serval:BIB_1A1C34CA4648
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
108
Number
17
Pages
7119-7124
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per kilogram body weight) among 12 population-based samples of European ancestry, comprising 26,316 individuals, with replication genotyping in an additional 21,185 individuals. SNP rs6943555 in autism susceptibility candidate 2 gene (AUTS2) was associated with alcohol consumption at genome-wide significance (P = 4 × 10(-8) to P = 4 × 10(-9)). We found a genotype-specific expression of AUTS2 in 96 human prefrontal cortex samples (P = 0.026) and significant (P < 0.017) differences in expression of AUTS2 in whole-brain extracts of mice selected for differences in voluntary alcohol consumption. Down-regulation of an AUTS2 homolog caused reduced alcohol sensitivity in Drosophila (P < 0.001). Our finding of a regulator of alcohol consumption adds knowledge to our understanding of genetic mechanisms influencing alcohol drinking behavior.
Keywords
Alcohol Drinking/genetics, Alcohol Drinking/metabolism, Animals, Drosophila melanogaster/genetics, Drosophila melanogaster/metabolism, European Continental Ancestry Group/genetics, Female, Gene Expression Regulation/genetics, Genome-Wide Association Study, Genotype, Humans, Male, Mice, Nuclear Proteins/biosynthesis, Nuclear Proteins/genetics, Polymorphism, Single Nucleotide, Proteins/genetics, Proteins/metabolism, Quantitative Trait, Heritable
Pubmed
Web of science
Open Access
Yes
Create date
04/05/2011 10:34
Last modification date
20/08/2019 13:51