A modified Hortega-Globus stain is superior to Bielschowsky and Bodian stains for demonstrating neuritic plaques.

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State: Public
Version: Final published version
License: All rights reserved
Serval ID
serval:BIB_199DCEEF3748
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A modified Hortega-Globus stain is superior to Bielschowsky and Bodian stains for demonstrating neuritic plaques.
Journal
Biotechnic & histochemistry
Author(s)
Bolle L., Maurer B., Janzer R.C.
ISSN
1052-0295 (Print)
ISSN-L
1052-0295
Publication state
Published
Issued date
03/1992
Peer-reviewed
Oui
Volume
67
Number
2
Pages
82-87
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Abstract
The quantitative assessment of the age-dependent number of neuritic plaques is essential for the diagnosis of Alzheimer type dementia. This study reports the superiority of a modified Hortega-Globus stain compared to Bielschowsky and Bodian stains applied to samples obtained from ten brains of patients with a clinical history of progressive dementia. In two of ten cases only the modified Hortega-Globus stain allowed confirmation of the diagnosis of senile dementia of the Alzheimer type (SDAT). The counts of neuritic plaques in sections stained by other methods were not sufficient to establish the histological diagnosis of SDAT. These results indicate that the choice of the most sensitive staining method is critical for the correct histopathologic diagnosis of the Alzheimer type dementia.
Keywords
Aged, Aged, 80 and over, Alzheimer Disease/diagnosis, Alzheimer Disease/pathology, Brain/pathology, Dementia/diagnosis, Dementia/pathology, Female, Humans, Male, Neuritis/pathology, Neurofibrillary Tangles/pathology, Sensitivity and Specificity, Staining and Labeling/methods
Pubmed
Web of science
Create date
20/10/2010 9:55
Last modification date
29/07/2020 7:08
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