A modified Hortega-Globus stain is superior to Bielschowsky and Bodian stains for demonstrating neuritic plaques.

Détails

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Etat: Public
Version: Final published version
Licence: Tous droits réservés
ID Serval
serval:BIB_199DCEEF3748
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A modified Hortega-Globus stain is superior to Bielschowsky and Bodian stains for demonstrating neuritic plaques.
Périodique
Biotechnic & histochemistry
Auteur(s)
Bolle L., Maurer B., Janzer R.C.
ISSN
1052-0295 (Print)
ISSN-L
1052-0295
Statut éditorial
Publié
Date de publication
03/1992
Peer-reviewed
Oui
Volume
67
Numéro
2
Pages
82-87
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Résumé
The quantitative assessment of the age-dependent number of neuritic plaques is essential for the diagnosis of Alzheimer type dementia. This study reports the superiority of a modified Hortega-Globus stain compared to Bielschowsky and Bodian stains applied to samples obtained from ten brains of patients with a clinical history of progressive dementia. In two of ten cases only the modified Hortega-Globus stain allowed confirmation of the diagnosis of senile dementia of the Alzheimer type (SDAT). The counts of neuritic plaques in sections stained by other methods were not sufficient to establish the histological diagnosis of SDAT. These results indicate that the choice of the most sensitive staining method is critical for the correct histopathologic diagnosis of the Alzheimer type dementia.
Mots-clé
Aged, Aged, 80 and over, Alzheimer Disease/diagnosis, Alzheimer Disease/pathology, Brain/pathology, Dementia/diagnosis, Dementia/pathology, Female, Humans, Male, Neuritis/pathology, Neurofibrillary Tangles/pathology, Sensitivity and Specificity, Staining and Labeling/methods
Pubmed
Web of science
Création de la notice
20/10/2010 9:55
Dernière modification de la notice
29/07/2020 7:08
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