Assessment of the role of the humoral response to Plasmodium falciparum MSP2 compared to RESA and SPf66 in protecting Papua New Guinean children from clinical malaria

Details

Serval ID
serval:BIB_194EB217CFF7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Assessment of the role of the humoral response to Plasmodium falciparum MSP2 compared to RESA and SPf66 in protecting Papua New Guinean children from clinical malaria
Journal
Parasite Immunology
Author(s)
al-Yaman  F., Genton  B., Anders  R., Taraika  J., Ginny  M., Mellor  S., Alpers  M. P.
ISSN
0141-9838 (Print)
Publication state
Published
Issued date
09/1995
Volume
17
Number
9
Pages
493-501
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Sep
Abstract
The prevalence and concentration of naturally acquired humoral response (IgG) to merozoite surface protein 2 (MSP2), RESA, SPf66 and crude schizont extract were measured in a population living in a malaria highly endemic area of Papua New Guinea. A prospective longitudinal study in 0.5-15 year old children was conducted for one year in order to examine the relationship between the humoral response to these antigens and subsequent susceptibility to clinical malaria using a series of clinical definitions. The prevalence and concentration of antibodies to all antigens increased with age. Such correlation with age was most marked for MSP2 recombinant proteins. When age and previous exposure were controlled for, only antibody levels to MSP2 recombinant proteins (3D7 and d3D7) and to RESA predicted a reduction in incidence rate of episodes of clinical malaria. Our results support the inclusion of the recombinant proteins of the 3D7 allelic family of merozoite surface antigen 2 and RESA into a subunit vaccine against malaria.
Keywords
Adolescent Aging Animals Antibodies, Protozoan/blood/*immunology Antigens, Protozoan/immunology Child Child, Preschool Humans Infant Longitudinal Studies Malaria Vaccines/immunology Malaria, Falciparum/epidemiology/*immunology Papua New Guinea Plasmodium falciparum/*immunology Prospective Studies Protozoan Proteins/*immunology *Recombinant Proteins Vaccines, Synthetic/immunology
Pubmed
Web of science
Create date
28/01/2008 11:49
Last modification date
20/08/2019 12:50
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