Assessment of the role of the humoral response to Plasmodium falciparum MSP2 compared to RESA and SPf66 in protecting Papua New Guinean children from clinical malaria

Détails

ID Serval
serval:BIB_194EB217CFF7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Assessment of the role of the humoral response to Plasmodium falciparum MSP2 compared to RESA and SPf66 in protecting Papua New Guinean children from clinical malaria
Périodique
Parasite Immunology
Auteur⸱e⸱s
al-Yaman  F., Genton  B., Anders  R., Taraika  J., Ginny  M., Mellor  S., Alpers  M. P.
ISSN
0141-9838 (Print)
Statut éditorial
Publié
Date de publication
09/1995
Volume
17
Numéro
9
Pages
493-501
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Sep
Résumé
The prevalence and concentration of naturally acquired humoral response (IgG) to merozoite surface protein 2 (MSP2), RESA, SPf66 and crude schizont extract were measured in a population living in a malaria highly endemic area of Papua New Guinea. A prospective longitudinal study in 0.5-15 year old children was conducted for one year in order to examine the relationship between the humoral response to these antigens and subsequent susceptibility to clinical malaria using a series of clinical definitions. The prevalence and concentration of antibodies to all antigens increased with age. Such correlation with age was most marked for MSP2 recombinant proteins. When age and previous exposure were controlled for, only antibody levels to MSP2 recombinant proteins (3D7 and d3D7) and to RESA predicted a reduction in incidence rate of episodes of clinical malaria. Our results support the inclusion of the recombinant proteins of the 3D7 allelic family of merozoite surface antigen 2 and RESA into a subunit vaccine against malaria.
Mots-clé
Adolescent Aging Animals Antibodies, Protozoan/blood/*immunology Antigens, Protozoan/immunology Child Child, Preschool Humans Infant Longitudinal Studies Malaria Vaccines/immunology Malaria, Falciparum/epidemiology/*immunology Papua New Guinea Plasmodium falciparum/*immunology Prospective Studies Protozoan Proteins/*immunology *Recombinant Proteins Vaccines, Synthetic/immunology
Pubmed
Web of science
Création de la notice
28/01/2008 11:49
Dernière modification de la notice
20/08/2019 12:50
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