GABA receptor subunits in human auditory cortex in normal and stroke cases.

Details

Serval ID
serval:BIB_19002C72D1AF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
GABA receptor subunits in human auditory cortex in normal and stroke cases.
Journal
Acta Neurobiologiae Experimentalis
Author(s)
Sacco Carolyn B., Tardif Er, Genoud Christel, Probst Alphonse, Tolnay Markus, Janzer Robert-Charles, Verney Catherine, Kraftsik Rudolf, Clarke Stephanie
ISSN
0065-1400
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
69
Number
4
Pages
469-493
Language
english
Abstract
GABA receptors are ubiquitous in the cerebral cortex and play a major role in shaping responses of cortical neurons. GABAA and GABAB receptor subunit expression was visualized by immunohistochemistry in human auditory areas from both hemispheres in 9 normal subjects (aged 43-85 years; time between death and fixation 6-24 hours) and in 4 stroke patients (aged 59-87 years; time between death and fixation 7-24 hours) and analyzed qualitatively for GABAA and semiquantitatively for GABAB receptor subunits. In normal brains, the primary auditory area (TC) and the surrounding areas TB and TA displayed distinct GABAA receptor subunit labeling with differences among cortical layers and areas. In postacute and chronic stroke we found a layer-selective downregulation of the alpha-2 subunit in the anatomically intact cerebral cortex of the intact and of the lesioned hemisphere, whereas the alpha-1, alpha-3 and beta-2/3 subunits maintained normal levels of expression. The GABAB receptors had a distinct laminar pattern in auditory areas and minor differences among areas. Unlike in other pathologies, there is no modulation of the GABAB receptor expression in subacute or chronic stroke.
Keywords
GABA, Human, Postlesional Plasticity, Diaschisis, Auditory, Temporal-Lobe Epilepsy, Electrophysiological Transcortical Diaschisis, Learning-Induced Plasticity, Extrastriate Visual-Cortex, Focal Hemispheric Lesions, Human Superior Colliculus, Calcium-Binding Proteins, Central-Nervous-System, Human Cerebral-Cortex, Cytochrome-Oxidase
Pubmed
Web of science
Create date
21/01/2010 10:00
Last modification date
20/08/2019 13:49
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