Knowing where and getting there: a human navigation network.

Details

Serval ID
serval:BIB_18E687BDD4F4
Type
Article: article from journal or magazin.
Collection
Publications
Title
Knowing where and getting there: a human navigation network.
Journal
Science
Author(s)
Maguire E.A., Burgess N., Donnett J.G., Frackowiak R.S., Frith C.D., O'Keefe J.
ISSN
0036-8075 (Print)
ISSN-L
0036-8075
Publication state
Published
Issued date
1998
Volume
280
Number
5365
Pages
921-924
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
The neural basis of navigation by humans was investigated with functional neuroimaging of brain activity during navigation in a familiar, yet complex virtual reality town. Activation of the right hippocampus was strongly associated with knowing accurately where places were located and navigating accurately between them. Getting to those places quickly was strongly associated with activation of the right caudate nucleus. These two right-side brain structures function in the context of associated activity in right inferior parietal and bilateral medial parietal regions that support egocentric movement through the virtual town, and activity in other left-side regions (hippocampus, frontal cortex) probably involved in nonspatial aspects of navigation. These findings outline a network of brain areas that support navigation in humans and link the functions of these regions to physiological observations in other mammals.
Keywords
Brain Mapping, Caudate Nucleus/blood supply, Caudate Nucleus/physiology, Cues, Frontal Lobe/blood supply, Frontal Lobe/physiology, Hippocampus/blood supply, Hippocampus/physiology, Humans, Male, Memory, Neural Pathways, Orientation, Parietal Lobe/blood supply, Parietal Lobe/physiology, Psychomotor Performance, Regional Blood Flow, Space Perception, Tomography, Emission-Computed
Pubmed
Web of science
Create date
16/09/2011 16:29
Last modification date
20/08/2019 12:49
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