The role of chemokines in cancer immune surveillance by the adaptive immune system.

Details

Serval ID
serval:BIB_185BDB857C33
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The role of chemokines in cancer immune surveillance by the adaptive immune system.
Journal
Seminars in Cancer Biology
Author(s)
Krieg C., Boyman O.
ISSN
1096-3650[electronic]
Publication state
Published
Issued date
2009
Volume
19
Number
2
Pages
76-83
Language
english
Abstract
Chemokines are key molecules involved in the migration and homeostasis of immune cells. However, also tumor cells use chemokine signals for different processes such as tumor progression and metastasis. It is thus unclear whether chemokines, through their immunostimulatory roles, contribute to the repression of tumor cells by tumor immunosurveillance or whether chemokines act primarily as growth factors and chemoattractants for primary and metastatizing tumors, respectively. Research of recent years, using gene knockout mice, recombinant chemokines, and agents able to block chemokine actions, has provided further insight into the diverse functions of chemokines. Here, we review the current knowledge on the complex actions of chemokines at the interface of the immune system and the tumor.
Pubmed
Web of science
Create date
23/03/2009 10:55
Last modification date
20/08/2019 12:48
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