The role of chemokines in cancer immune surveillance by the adaptive immune system.

Détails

ID Serval
serval:BIB_185BDB857C33
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The role of chemokines in cancer immune surveillance by the adaptive immune system.
Périodique
Seminars in Cancer Biology
Auteur(s)
Krieg C., Boyman O.
ISSN
1096-3650[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
19
Numéro
2
Pages
76-83
Langue
anglais
Résumé
Chemokines are key molecules involved in the migration and homeostasis of immune cells. However, also tumor cells use chemokine signals for different processes such as tumor progression and metastasis. It is thus unclear whether chemokines, through their immunostimulatory roles, contribute to the repression of tumor cells by tumor immunosurveillance or whether chemokines act primarily as growth factors and chemoattractants for primary and metastatizing tumors, respectively. Research of recent years, using gene knockout mice, recombinant chemokines, and agents able to block chemokine actions, has provided further insight into the diverse functions of chemokines. Here, we review the current knowledge on the complex actions of chemokines at the interface of the immune system and the tumor.
Pubmed
Web of science
Création de la notice
23/03/2009 11:55
Dernière modification de la notice
20/08/2019 13:48
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