Closed-loop Neuropharmacology for Epilepsy: Distant Dream or Future Reality?

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Serval ID
serval:BIB_185B655D5EFA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Closed-loop Neuropharmacology for Epilepsy: Distant Dream or Future Reality?
Journal
Current neuropharmacology
Author(s)
Aicua-Rapun I., André P., Novy J.
ISSN
1875-6190 (Electronic)
ISSN-L
1570-159X
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
17
Number
5
Pages
447-458
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Epilepsy is considered the most frequent severe neurological condition but most patients treated with medication become seizure free. The management of treatment, however, is highly empirical, mainly relying on observation. A closed-loop therapy for epilepsy would be very valuable for more efficient treatment regimens. Here we discuss monitoring treatment (therapeutic drug monitoring) and the potential developments in this field, as well as providing a review of potential biomarkers that could be used to monitor the disease activity. Finally, we consider the pharmacogenetic input in epilepsy treatment.
Keywords
Anticonvulsants/pharmacology, Anticonvulsants/therapeutic use, Biomarkers/metabolism, Cytokines/metabolism, Drug Monitoring/methods, Epilepsy/drug therapy, Epilepsy/genetics, Epilepsy/metabolism, Hormones/metabolism, Humans, Neuropharmacology, Pharmacogenetics, Randomized Controlled Trials as Topic, Biomarkers in epilepsy, cytokines, genetic factors, hormones, pharmacogenetics, refractory epilepsy, therapeutic drug monitoring.
Pubmed
Web of science
Create date
15/03/2018 19:07
Last modification date
17/09/2020 8:14
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