Transcriptomics-driven lipidomics (TDL) identifies the microbiome-regulated targets of ileal lipid metabolism.

Details

Serval ID
serval:BIB_181540936840
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Transcriptomics-driven lipidomics (TDL) identifies the microbiome-regulated targets of ileal lipid metabolism.
Journal
NPJ systems biology and applications
Author(s)
Chakrabarti A., Membrez M., Morin-Rivron D., Siddharth J., Chou C.J., Henry H., Bruce S., Metairon S., Raymond F., Betrisey B., Loyer C., Parkinson S.J., Masoodi M.
ISSN
2056-7189 (Print)
ISSN-L
2056-7189
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
3
Pages
33
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The gut microbiome and lipid metabolism are both recognized as essential components in the maintenance of metabolic health. The mechanisms involved are multifactorial and (especially for microbiome) poorly defined. A strategic approach to investigate the complexity of the microbial influence on lipid metabolism would facilitate determination of relevant molecular mechanisms for microbiome-targeted therapeutics. E. coli is associated with obesity and metabolic syndrome and we used this association in conjunction with gnotobiotic models to investigate the impact of E. coli on lipid metabolism. To address the complexities of the integration of the microbiome and lipid metabolism, we developed transcriptomics-driven lipidomics (TDL) to predict the impact of E. coli colonization on lipid metabolism and established mediators of inflammation and insulin resistance including arachidonic acid metabolism, alterations in bile acids and dietary lipid absorption. A microbiome-related therapeutic approach targeting these mechanisms may therefore provide a therapeutic avenue supporting maintenance of metabolic health.

Pubmed
Open Access
Yes
Create date
16/11/2017 20:11
Last modification date
20/08/2019 12:48
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