A research agenda for malaria eradication: vaccines.

Details

Serval ID
serval:BIB_17D4358B17E9
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
A research agenda for malaria eradication: vaccines.
Journal
Plos Medicine
Working group(s)
malERA Consultative Group on Vaccines
Contributor(s)
Abdulla S., Agre P., Alonso PL., Arevalo-Herrera M., Bassat Q., Binka F., Chitnis C., Corradin G., Cowman A., Culpepper J., del Portillo H., Dinglasan R., Duffy P., Gargallo D., Greenwood B., Guinovart C., Hall BF., Herrera£££Sócrates£££ S. , Hoffman S., Lanzavecchia A., Leroy O., Levine MM., Loucq C., Mendis K., Milman J., Moorthy V., Pleuschke G., Plowe CV., Reed S., Sauerwein R., Saul A., Schofield L., Sinden R., Stubbs J., Villafana T., Wirth D., Yadav P., Ballou R., Brown G., Birkett A., Brandt W., Brooks A., Carter T., Golden A., Lee C., Nunes J., Puijalon O., Raphael T., Richards H., Warren C., Woods C.
ISSN
1549-1676 (Electronic)
ISSN-L
1549-1277
Publication state
Published
Issued date
2011
Volume
8
Number
1
Pages
e1000398
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
Abstract
Vaccines could be a crucial component of efforts to eradicate malaria. Current attempts to develop malaria vaccines are primarily focused on Plasmodium falciparum and are directed towards reducing morbidity and mortality. Continued support for these efforts is essential, but if malaria vaccines are to be used as part of a repertoire of tools for elimination or eradication of malaria, they will need to have an impact on malaria transmission. We introduce the concept of "vaccines that interrupt malaria transmission" (VIMT), which includes not only "classical" transmission-blocking vaccines that target the sexual and mosquito stages but also pre-erythrocytic and asexual stage vaccines that have an effect on transmission. VIMT may also include vaccines that target the vector to disrupt parasite development in the mosquito. Importantly, if eradication is to be achieved, malaria vaccine development efforts will need to target other malaria parasite species, especially Plasmodium vivax, where novel therapeutic vaccines against hypnozoites or preventive vaccines with effect against multiple stages could have enormous impact. A target product profile (TPP) for VIMT is proposed and a research agenda to address current knowledge gaps and develop tools necessary for design and development of VIMT is presented.
Keywords
Animals, Anopheles/parasitology, Clinical Trials as Topic, Decision Making, Disease Outbreaks/prevention & control, Host-Parasite Interactions, Humans, Insect Vectors/parasitology, Licensure, Malaria/prevention & control, Malaria/transmission, Malaria Vaccines, Malaria, Falciparum/prevention & control, Malaria, Falciparum/transmission, Malaria, Vivax/prevention & control, Malaria, Vivax/transmission, Parasitemia/parasitology, Parasitemia/prevention & control, Plasmodium falciparum/immunology, Plasmodium falciparum/physiology, Plasmodium vivax/growth & development, Plasmodium vivax/immunology, Reproduction, Research, Species Specificity, Translational Medical Research
Pubmed
Web of science
Open Access
Yes
Create date
09/02/2012 10:21
Last modification date
20/08/2019 12:47
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