Full-term pregnancy with embryos from donated oocytes in a 36-year-old woman allografted for chronic myeloid leukemia
Details
Serval ID
serval:BIB_17644C00AEDE
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Full-term pregnancy with embryos from donated oocytes in a 36-year-old woman allografted for chronic myeloid leukemia
Journal
Bone Marrow Transplantation
ISSN
0268-3369
Publication state
Published
Issued date
04/1994
Peer-reviewed
Oui
Volume
13
Number
4
Pages
487-8
Notes
Case Reports
Journal Article --- Old month value: Apr
Journal Article --- Old month value: Apr
Abstract
We report the first case of full-term pregnancy arising from donated oocytes in a 36-year-old woman with chronic myeloid leukemia (CML), 6 years after allogeneic bone marrow transplantation (BMT) following total body irradiation (TBI) (12 Gy) and cyclophosphamide 120 mg/kg. The first attempt at implantation with her own cryopreserved ovocytes was unsuccessful. Thereafter, she became pregnant after donated oocyte implantation using estradiol and progesterone support replacing the defective ovarian function. The baby was normal. Unfortunately, 6 months later, she relapsed in chronic phase of CML.
Keywords
Adult
*Bone Marrow Transplantation
Cyclophosphamide/administration & dosage
*Embryo Transfer
Estradiol/therapeutic use
Female
Humans
Infant, Newborn
Infertility, Female/etiology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*therapy
Leukemia, Myeloid, Chronic-Phase/etiology
*Oocytes
Ovarian Failure, Premature/drug therapy/etiology
Ovary/radiation effects
Pregnancy
*Pregnancy Outcome
Progesterone/therapeutic use
Radiation Injuries/etiology
Tissue Donors
Whole-Body Irradiation/adverse effects
Pubmed
Web of science
Create date
28/02/2008 11:37
Last modification date
20/08/2019 12:47