A standard calculation methodology for human doubly labeled water studies.

Details

Serval ID
serval:BIB_160A236A5A5F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A standard calculation methodology for human doubly labeled water studies.
Journal
Cell reports. Medicine
Author(s)
Speakman J.R., Yamada Y., Sagayama H., Berman ESF, Ainslie P.N., Andersen L.F., Anderson L.J., Arab L., Baddou I., Bedu-Addo K., Blaak E.E., Blanc S., Bonomi A.G., Bouten CVC, Bovet P., Buchowski M.S., Butte N.F., Camps SGJA, Close G.L., Cooper J.A., Creasy S.A., Das S.K., Cooper R., Dugas L.R., Ebbeling C.B., Ekelund U., Entringer S., Forrester T., Fudge B.W., Goris A.H., Gurven M., Hambly C., El Hamdouchi A., Hoos M.B., Hu S., Joonas N., Joosen A.M., Katzmarzyk P., Kempen K.P., Kimura M., Kraus W.E., Kushner R.F., Lambert E.V., Leonard W.R., Lessan N., Ludwig D.S., Martin C.K., Medin A.C., Meijer E.P., Morehen J.C., Morton J.P., Neuhouser M.L., Nicklas T.A., Ojiambo R.M., Pietiläinen K.H., Pitsiladis Y.P., Plange-Rhule J., Plasqui G., Prentice R.L., Rabinovich R.A., Racette S.B., Raichlen D.A., Ravussin E., Reynolds R.M., Roberts S.B., Schuit A.J., Sjödin A.M., Stice E., Urlacher S.S., Valenti G., Van Etten L.M., Van Mil E.A., Wells JCK, Wilson G., Wood B.M., Yanovski J., Yoshida T., Zhang X., Murphy-Alford A.J., Loechl C.U., Melanson E.L., Luke A.H., Pontzer H., Rood J., Schoeller D.A., Westerterp K.R., Wong W.W.
Working group(s)
IAEA DLW database group
ISSN
2666-3791 (Electronic)
ISSN-L
2666-3791
Publication state
Published
Issued date
16/02/2021
Peer-reviewed
Oui
Volume
2
Number
2
Pages
100203
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO <sub>2</sub> is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<10 kg). Using data for 1,021 babies and infants, we show that the DSR varies non-linearly with body mass between 0 and 10 kg. Using this relationship to predict DSR from weight provides an equation for rCO <sub>2</sub> over this size range that agrees well with indirect calorimetry (average difference 0.64%; SD = 12.2%). We propose adoption of these equations in future studies.
Keywords
doubly labeled water, free-living, total energy expenditure, validation
Pubmed
Web of science
Open Access
Yes
Create date
16/03/2021 10:25
Last modification date
08/05/2021 6:32
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