Platelet count and outcome in patients with acute venous thromboembolism.

Details

Serval ID
serval:BIB_15E813BB5B2E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Platelet count and outcome in patients with acute venous thromboembolism.
Journal
Thrombosis and Haemostasis
Author(s)
Di Micco P., Ruiz-Giménez N., Nieto J.A., Aujesky D., del Molino F., Valle R., Barrón M., Maestre A., Monreal M.
Working group(s)
RIETE investigators
Contributor(s)
Monreal M., Decousus H., Prandoni P., Brenner B., Barba R., Di Micco P., Bertoletti L., Schellong S., Tzoran I., Dr Abilio R., Bosevski M., Bounameaux H., Malý R., Andújar V., Arcelus JI., Arroyo M., Ballaz A., Barba R., Barrón M., Barrón-Andrés B., Bascuñana J., Bedate P., Benítez JF., Blanco- Molina A., Boix L., Bosco J., Bueso T., Casado I., Chaves E., Contra A., de Ancos CL. , de Miguel J., del Molino F., del Toro J., Elías-Hernández T., Falgá C., Farfán A., Fernández-Capitán C., Fole D., Font C., Fuentes MI., Gallego P., García-Bragado F., Gavín O., Gómez V., González J., González-Basch E., González-Nieto JA., Grau E., Guil M., Guijarro R., Gutiérrez J., Hernández L., Hernández-Huerta S., Jara L., Jaras MJ., Jiménez D., Lecumberri R., Lobo JL., López-Jiménez L., López L., Lorenzo A., Luque JM., Macià M., Madridano O., Maestre A., Marchena PJ., Martín M., Martín-Villasclaras JJ., Monreal M., Muñoz FJ., Nauffal MD., Nieto JA., Núñez MJ., Ogea JL., Otero R., Paul HE., Pedrajas JM., Peris ML., Quezada CA., Riera-Mestre A., Rivas A., Rodríguez-Dávila MA., Román P., Rosa V., Ruíz J., Ruiz-Gamietea A., Ruiz-Giménez N., Sahuquillo JC., Sánchez R., Sánchez Muñoz-Torrero JF. , Soler S., Soto MJ., Toda M., Todolí JA., Tolosa C., Trujillo J., Valdés M., Valero B., Valle R., Vela J., Vidal G., Vilar C., Villalobos A., Villalta J., Zorrilla V., Gadelha T., Malý R., Hirmerova J., Miklosovà M., Salgado E., Bertoletti L., Bura-Riviere A., Farge-Bancel D., Mahe I., Merah A., Quere I., Schellong S., Faul J., Braester A., Brenner B., Tzoran I., Zeltser D., Barillari G., Ciammaichella M., Di Micco P., Dalla Valle F., Duce R., Maida R., Pasca S., Piovella C., Poggio R., Prandoni P., Quintavalla R., Rocci A., Rota L., Schenone A., Tiraferri E., Tonello D., Tufano A., Visonà A., Zalunardo B., Cardoso C., Santos M., Saraiva M., Bosevski M., Aujeski D., Bounameaux H., Mazzolai L., Caprini J.
ISSN
0340-6245 (Print)
ISSN-L
0340-6245
Publication state
Published
Issued date
2013
Volume
110
Number
5
Pages
1025-1034
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
The relationship between platelet count and outcome in patients with acute venous thromboembolism (VTE) has not been consistently explored. RIETE is an ongoing registry of consecutive patients with acute VTE. We categorised patients as having very low- (<80,000/µl), low- (80,000/µl to 150,000/µl), normal- (150,000/µl to 300,000/µl), high- (300,000/µl to 450,000/µl), or very high (>450,000/µl) platelet count at baseline, and compared their three-month outcome. As of October 2012, 43,078 patients had been enrolled in RIETE: 21,319 presenting with pulmonary embolism and 21,759 with deep-vein thrombosis. In all, 502 patients (1.2%) had very low-; 5,472 (13%) low-; 28,386 (66%) normal-; 7,157 (17%) high-; and 1,561 (3.6%) very high platelet count. During the three-month study period, the recurrence rate was: 2.8%, 2.2%, 1.8%, 2.1% and 2.2%, respectively; the rate of major bleeding: 5.8%, 2.6%, 1.7%, 2.3% and 4.6%, respectively; the rate of fatal bleeding: 2.0%, 0.9%, 0.3%, 0.5% and 1.2%, respectively; and the mortality rate: 29%, 11%, 6.5%, 8.8% and 14%, respectively. On multivariate analysis, patients with very low-, low-, high- or very high platelet count had an increased risk for major bleeding (odds ratio [OR]: 2.70, 95% confidence interval [CI]: 1.85-3.95; 1.43 [1.18-1.72]; 1.23 [1.03-1.47]; and 2.13 [1.65-2.75]) and fatal bleeding (OR: 3.70 [1.92-7.16], 2.10 [1.48-2.97], 1.29 [0.88-1.90] and 2.49 [1.49-4.15]) compared with those with normal count. In conclusion, we found a U-shaped relationship between platelet count and the three-month rate of major bleeding and fatal bleeding in patients with VTE.
Pubmed
Web of science
Create date
13/02/2014 15:28
Last modification date
20/08/2019 12:45
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