Platelet count and outcome in patients with acute venous thromboembolism.

Détails

ID Serval
serval:BIB_15E813BB5B2E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Platelet count and outcome in patients with acute venous thromboembolism.
Périodique
Thrombosis and Haemostasis
Auteur(s)
Di Micco P., Ruiz-Giménez N., Nieto J.A., Aujesky D., del Molino F., Valle R., Barrón M., Maestre A., Monreal M.
Collaborateur(s)
RIETE investigators
Contributeur(s)
Monreal M., Decousus H., Prandoni P., Brenner B., Barba R., Di Micco P., Bertoletti L., Schellong S., Tzoran I., Dr Abilio R., Bosevski M., Bounameaux H., Malý R., Andújar V., Arcelus JI., Arroyo M., Ballaz A., Barba R., Barrón M., Barrón-Andrés B., Bascuñana J., Bedate P., Benítez JF., Blanco- Molina A., Boix L., Bosco J., Bueso T., Casado I., Chaves E., Contra A., de Ancos CL. , de Miguel J., del Molino F., del Toro J., Elías-Hernández T., Falgá C., Farfán A., Fernández-Capitán C., Fole D., Font C., Fuentes MI., Gallego P., García-Bragado F., Gavín O., Gómez V., González J., González-Basch E., González-Nieto JA., Grau E., Guil M., Guijarro R., Gutiérrez J., Hernández L., Hernández-Huerta S., Jara L., Jaras MJ., Jiménez D., Lecumberri R., Lobo JL., López-Jiménez L., López L., Lorenzo A., Luque JM., Macià M., Madridano O., Maestre A., Marchena PJ., Martín M., Martín-Villasclaras JJ., Monreal M., Muñoz FJ., Nauffal MD., Nieto JA., Núñez MJ., Ogea JL., Otero R., Paul HE., Pedrajas JM., Peris ML., Quezada CA., Riera-Mestre A., Rivas A., Rodríguez-Dávila MA., Román P., Rosa V., Ruíz J., Ruiz-Gamietea A., Ruiz-Giménez N., Sahuquillo JC., Sánchez R., Sánchez Muñoz-Torrero JF. , Soler S., Soto MJ., Toda M., Todolí JA., Tolosa C., Trujillo J., Valdés M., Valero B., Valle R., Vela J., Vidal G., Vilar C., Villalobos A., Villalta J., Zorrilla V., Gadelha T., Malý R., Hirmerova J., Miklosovà M., Salgado E., Bertoletti L., Bura-Riviere A., Farge-Bancel D., Mahe I., Merah A., Quere I., Schellong S., Faul J., Braester A., Brenner B., Tzoran I., Zeltser D., Barillari G., Ciammaichella M., Di Micco P., Dalla Valle F., Duce R., Maida R., Pasca S., Piovella C., Poggio R., Prandoni P., Quintavalla R., Rocci A., Rota L., Schenone A., Tiraferri E., Tonello D., Tufano A., Visonà A., Zalunardo B., Cardoso C., Santos M., Saraiva M., Bosevski M., Aujeski D., Bounameaux H., Mazzolai L., Caprini J.
ISSN
0340-6245 (Print)
ISSN-L
0340-6245
Statut éditorial
Publié
Date de publication
2013
Volume
110
Numéro
5
Pages
1025-1034
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The relationship between platelet count and outcome in patients with acute venous thromboembolism (VTE) has not been consistently explored. RIETE is an ongoing registry of consecutive patients with acute VTE. We categorised patients as having very low- (<80,000/µl), low- (80,000/µl to 150,000/µl), normal- (150,000/µl to 300,000/µl), high- (300,000/µl to 450,000/µl), or very high (>450,000/µl) platelet count at baseline, and compared their three-month outcome. As of October 2012, 43,078 patients had been enrolled in RIETE: 21,319 presenting with pulmonary embolism and 21,759 with deep-vein thrombosis. In all, 502 patients (1.2%) had very low-; 5,472 (13%) low-; 28,386 (66%) normal-; 7,157 (17%) high-; and 1,561 (3.6%) very high platelet count. During the three-month study period, the recurrence rate was: 2.8%, 2.2%, 1.8%, 2.1% and 2.2%, respectively; the rate of major bleeding: 5.8%, 2.6%, 1.7%, 2.3% and 4.6%, respectively; the rate of fatal bleeding: 2.0%, 0.9%, 0.3%, 0.5% and 1.2%, respectively; and the mortality rate: 29%, 11%, 6.5%, 8.8% and 14%, respectively. On multivariate analysis, patients with very low-, low-, high- or very high platelet count had an increased risk for major bleeding (odds ratio [OR]: 2.70, 95% confidence interval [CI]: 1.85-3.95; 1.43 [1.18-1.72]; 1.23 [1.03-1.47]; and 2.13 [1.65-2.75]) and fatal bleeding (OR: 3.70 [1.92-7.16], 2.10 [1.48-2.97], 1.29 [0.88-1.90] and 2.49 [1.49-4.15]) compared with those with normal count. In conclusion, we found a U-shaped relationship between platelet count and the three-month rate of major bleeding and fatal bleeding in patients with VTE.
Pubmed
Web of science
Création de la notice
13/02/2014 15:28
Dernière modification de la notice
20/08/2019 12:45
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