d-Amphetamine-induced anorexia and motor behavior after chronic treatment in rats: relationship with changes in the number of catecholamine receptor sites in the brain.

Details

Serval ID
serval:BIB_157CDB216B00
Type
Article: article from journal or magazin.
Collection
Publications
Title
d-Amphetamine-induced anorexia and motor behavior after chronic treatment in rats: relationship with changes in the number of catecholamine receptor sites in the brain.
Journal
Archives Internationales de Pharmacodynamie et de Thérapie
Author(s)
Bendotti C., Borsini F., Cotecchia S., De Blasi A., Mennini T., Samanin R.
ISSN
0003-9780 (Print)
ISSN-L
0003-9780
Publication state
Published
Issued date
1982
Volume
260
Number
1
Pages
36-49
Language
english
Abstract
No tolerance to the anorectic activity of d-amphetamine was found in rats given two daily injections of 1.25 mg/kg for 28 days. Such rats also presented no changes in the number of binding sites for serotonin and catecholamines in various brain areas. A 28-day treatment with 10 mg/kg d-amphetamine twice daily caused a significant reduction in the number of binding sites for 3H-dihydroalprenolol (beta adrenergic receptor ligand) in hippocampus, and 3H-spiroperidol (dopamine receptor ligand) in striatum and nucleus accumbens. This treatment did not modify the anorectic effect of 1.25 mg/kg of amphetamine but it markedly reduced the motor hyperactivity induced by this treatment and completely blocked the stereotyped licking and biting induced by apomorphine. Amphetamine stereotypy was not significantly reduced but disappeared faster in chronically treated rats. The possible reasons for the different results (tolerance or sensitization) reported by various authors on changes in amphetamine's effects on motor behaviour during chronic treatment are discussed.
Keywords
Animals, Anorexia/chemically induced, Brain/drug effects, Dextroamphetamine/metabolism, Dextroamphetamine/pharmacology, Drug Tolerance, Eating Disorders/chemically induced, Humans, Male, Motor Activity/drug effects, Rats, Rats, Inbred Strains, Receptors, Adrenergic/drug effects, Receptors, Dopamine/drug effects, Receptors, Serotonin/drug effects, Stereotyped Behavior/drug effects
Pubmed
Web of science
Create date
24/01/2008 11:05
Last modification date
20/08/2019 12:44
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