d-Amphetamine-induced anorexia and motor behavior after chronic treatment in rats: relationship with changes in the number of catecholamine receptor sites in the brain.

Détails

ID Serval
serval:BIB_157CDB216B00
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
d-Amphetamine-induced anorexia and motor behavior after chronic treatment in rats: relationship with changes in the number of catecholamine receptor sites in the brain.
Périodique
Archives Internationales de Pharmacodynamie et de Thérapie
Auteur(s)
Bendotti C., Borsini F., Cotecchia S., De Blasi A., Mennini T., Samanin R.
ISSN
0003-9780 (Print)
ISSN-L
0003-9780
Statut éditorial
Publié
Date de publication
1982
Volume
260
Numéro
1
Pages
36-49
Langue
anglais
Résumé
No tolerance to the anorectic activity of d-amphetamine was found in rats given two daily injections of 1.25 mg/kg for 28 days. Such rats also presented no changes in the number of binding sites for serotonin and catecholamines in various brain areas. A 28-day treatment with 10 mg/kg d-amphetamine twice daily caused a significant reduction in the number of binding sites for 3H-dihydroalprenolol (beta adrenergic receptor ligand) in hippocampus, and 3H-spiroperidol (dopamine receptor ligand) in striatum and nucleus accumbens. This treatment did not modify the anorectic effect of 1.25 mg/kg of amphetamine but it markedly reduced the motor hyperactivity induced by this treatment and completely blocked the stereotyped licking and biting induced by apomorphine. Amphetamine stereotypy was not significantly reduced but disappeared faster in chronically treated rats. The possible reasons for the different results (tolerance or sensitization) reported by various authors on changes in amphetamine's effects on motor behaviour during chronic treatment are discussed.
Mots-clé
Animals, Anorexia/chemically induced, Brain/drug effects, Dextroamphetamine/metabolism, Dextroamphetamine/pharmacology, Drug Tolerance, Eating Disorders/chemically induced, Humans, Male, Motor Activity/drug effects, Rats, Rats, Inbred Strains, Receptors, Adrenergic/drug effects, Receptors, Dopamine/drug effects, Receptors, Serotonin/drug effects, Stereotyped Behavior/drug effects
Pubmed
Web of science
Création de la notice
24/01/2008 11:05
Dernière modification de la notice
20/08/2019 12:44
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