Signaling by ROS drives inflammasome activation.
Details
Serval ID
serval:BIB_1463B2B8CF67
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Signaling by ROS drives inflammasome activation.
Journal
European Journal of Immunology
ISSN
1521-4141 (Electronic)
ISSN-L
0014-2980
Publication state
Published
Issued date
2010
Volume
40
Number
3
Pages
616-619
Language
english
Abstract
Inflammasomes are innate immune signaling pathways that sense pathogens and injury to direct the proteolytic maturation of inflammatory cytokines such as IL-1beta and IL-18. Among inflammasomes, the NLRP3/NALP3 inflammasome is the most studied. However, little is known on the molecular mechanisms that mediate its assembly and activation. Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation.
Keywords
Animals, Carrier Proteins/immunology, Humans, Inflammation/immunology, Multiprotein Complexes/immunology, Oxidative Stress/immunology, Reactive Oxygen Species/immunology, Signal Transduction/immunology
Pubmed
Web of science
Open Access
Yes
Create date
21/02/2011 15:36
Last modification date
20/08/2019 12:43
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