Signaling by ROS drives inflammasome activation.
Détails
ID Serval
serval:BIB_1463B2B8CF67
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Signaling by ROS drives inflammasome activation.
Périodique
European Journal of Immunology
ISSN
1521-4141 (Electronic)
ISSN-L
0014-2980
Statut éditorial
Publié
Date de publication
2010
Volume
40
Numéro
3
Pages
616-619
Langue
anglais
Résumé
Inflammasomes are innate immune signaling pathways that sense pathogens and injury to direct the proteolytic maturation of inflammatory cytokines such as IL-1beta and IL-18. Among inflammasomes, the NLRP3/NALP3 inflammasome is the most studied. However, little is known on the molecular mechanisms that mediate its assembly and activation. Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation.
Mots-clé
Animals, Carrier Proteins/immunology, Humans, Inflammation/immunology, Multiprotein Complexes/immunology, Oxidative Stress/immunology, Reactive Oxygen Species/immunology, Signal Transduction/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/02/2011 15:36
Dernière modification de la notice
20/08/2019 12:43
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