p53 and the CNS: tumors and developmental abnormalities.

Details

Ressource 1Download: serval:BIB_13193.P001 (1473.11 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_13193
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
p53 and the CNS: tumors and developmental abnormalities.
Journal
Molecular Neurobiology
Author(s)
Fulci G., Van Meir E.G.
ISSN
0893-7648 (Print)
ISSN-L
0893-7648
Publication state
Published
Issued date
1999
Volume
19
Number
1
Pages
61-77
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
This article reviews the recent molecular and clinical studies that characterize the role of p53 in pathologies of the central nervous system, p53 has many important biological functions, notably, maintenance of DNA stability and regulation of apoptosis. These features are essential to avoid cellular transformation and ensure normal brain development. Lack of p53 function in the brain results in tumor formation in the astrocytic and lymphoid lineages and in severe neurodevelopmental diseases, such as exencephaly.
Keywords
Animals, Apoptosis, Brain/abnormalities, Brain/growth & development, Cell Cycle, Cell Differentiation, Cell Transformation, Neoplastic, Central Nervous System/abnormalities, Central Nervous System/growth & development, Central Nervous System Neoplasms/genetics, Central Nervous System Neoplasms/metabolism, Gene Expression Regulation, Developmental, Genes, p53, Humans, Tumor Suppressor Protein p53/genetics, Tumor Suppressor Protein p53/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2007 12:04
Last modification date
01/10/2019 6:16
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