Aquaporins in neurological disorders

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Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_0FF38E1931E3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Aquaporins in neurological disorders
Journal
Clinical and Translational Neuroscience
Author(s)
Hirt Lorenz, Price Melanie, Benakis Corinne, Badaut Jérôme
ISSN
2514-183X
2514-183X
Publication state
Published
Issued date
01/2018
Peer-reviewed
Oui
Volume
2
Number
1
Pages
2514183X1775290
Language
english
Abstract
Aquaporins (AQPs) are water channel molecules that allow the passage of water through the lipid bilayers of cell membranes. AQP1, AQP4 and AQP9 are expressed in the central nervous system and AQP4 is well known as the target of auto-antibodies in Devic’s neuromyelitis optica. The role of AQPs in facilitating water movements suggests a link with
oedema formation and resolution in the brain. Furthermore, AQPs are also involved in process formation in glial cells with a close link to neuroinflammation. This mini-review gives an overview of what is currently known about the role of AQPs in different neurological disorders.
Open Access
Yes
Create date
09/02/2018 12:19
Last modification date
08/05/2020 7:08
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