Successful treatment of trilateral retinoblastoma with conventional and high-dose chemotherapy plus radiotherapy: a case report.

Details

Serval ID
serval:BIB_0F14E493E4D1
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Successful treatment of trilateral retinoblastoma with conventional and high-dose chemotherapy plus radiotherapy: a case report.
Journal
Journal of Pediatric Hematology/oncology
Author(s)
De Ioris M.A., Fidani P., Munier F.L., Serra A., Ilari I., Popovic M.B., Natali G., Secco D.E., Cozza R.
ISSN
1536-3678 (Electronic)
ISSN-L
1077-4114
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
32
Number
8
Pages
e343-e345
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
Trilateral retinoblastoma (TRB) is a rare condition characterized by an intracranial neuroblastic tumor associated with bilateral or unilateral retinoblastoma (RB). The outcome is almost always fatal. An 18-month-old patient with familial bilateral RB was referred for a pineal lesion detected on a screening by magnetic resonance imaging. The child, considered inoperable by 2 different neurosurgical teams, was treated with conventional chemotherapy (methotrexate, vincristine, vepeside, cyclophosphamide, and carboplatin) plus tandem transplantation (vepeside/carboplatin and thiotepa/mephalan) followed by local radiotherapy. At 80 months from the diagnosis of TRB, the patient is alive and in complete remission, with no neuropsychologic consequences. An early and aggressive treatment may improve the prognosis of TRB.
Keywords
Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Combined Modality Therapy, Humans, Infant, Magnetic Resonance Imaging, Pinealoma/drug therapy, Pinealoma/pathology, Prognosis, Radiation Dosage, Radiotherapy, Remission Induction, Retinoblastoma/drug therapy, Retinoblastoma/pathology
Pubmed
Web of science
Create date
05/10/2010 9:22
Last modification date
20/08/2019 12:35
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