Genetic, ethnic, and gender differences in the pharmacokinetics of antiretroviral agents.

Details

Serval ID
serval:BIB_0F093BA5B5B6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Genetic, ethnic, and gender differences in the pharmacokinetics of antiretroviral agents.
Journal
Current HIV/AIDS reports
Author(s)
Rotger M., Csajka C., Telenti A.
ISSN
1548-3568
Publication state
Published
Issued date
09/2006
Volume
3
Number
3
Pages
118-25
Language
english
Notes
Publication types: Journal Article ; Review
Abstract
Variable antiretroviral therapy (ART) drug response likely reflects the combined influence of environment, underlying disease, concurrent drugs, and genetics. Gender exerts modest or negligible effects on ART disposition, and it is expected to have limited clinical implication, although it should be accounted for in large population studies. Ethnic denominations have, with the notable exception of efavirenz, no clear influence on ART disposition. Exploration of genetic factors might offer a better comprehension to the largely unpredictable and unresolved variability in ART concentrations and related toxicity or treatment outcome. Despite the negative perception of genetic research among the general public, this type of investigation is now widely accepted by concerned parties: patients, relatives, and study volunteers.
Keywords
Anti-HIV Agents/pharmacokinetics, Continental Population Groups, Ethnic Groups, Female, Genetic Variation, Humans, Male, Sex Characteristics
Pubmed
Create date
25/01/2008 10:48
Last modification date
20/08/2019 12:35
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