Genetic, ethnic, and gender differences in the pharmacokinetics of antiretroviral agents.

Détails

ID Serval
serval:BIB_0F093BA5B5B6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Genetic, ethnic, and gender differences in the pharmacokinetics of antiretroviral agents.
Périodique
Current HIV/AIDS reports
Auteur(s)
Rotger M., Csajka C., Telenti A.
ISSN
1548-3568
Statut éditorial
Publié
Date de publication
09/2006
Volume
3
Numéro
3
Pages
118-25
Langue
anglais
Notes
Publication types: Journal Article ; Review
Résumé
Variable antiretroviral therapy (ART) drug response likely reflects the combined influence of environment, underlying disease, concurrent drugs, and genetics. Gender exerts modest or negligible effects on ART disposition, and it is expected to have limited clinical implication, although it should be accounted for in large population studies. Ethnic denominations have, with the notable exception of efavirenz, no clear influence on ART disposition. Exploration of genetic factors might offer a better comprehension to the largely unpredictable and unresolved variability in ART concentrations and related toxicity or treatment outcome. Despite the negative perception of genetic research among the general public, this type of investigation is now widely accepted by concerned parties: patients, relatives, and study volunteers.
Mots-clé
Anti-HIV Agents/pharmacokinetics, Continental Population Groups, Ethnic Groups, Female, Genetic Variation, Humans, Male, Sex Characteristics
Pubmed
Création de la notice
25/01/2008 10:48
Dernière modification de la notice
20/08/2019 12:35
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