Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Genetic, ethnic, and gender differences in the pharmacokinetics of antiretroviral agents.
Current HIV/AIDS reports
Publication types: Journal Article ; Review
Variable antiretroviral therapy (ART) drug response likely reflects the combined influence of environment, underlying disease, concurrent drugs, and genetics. Gender exerts modest or negligible effects on ART disposition, and it is expected to have limited clinical implication, although it should be accounted for in large population studies. Ethnic denominations have, with the notable exception of efavirenz, no clear influence on ART disposition. Exploration of genetic factors might offer a better comprehension to the largely unpredictable and unresolved variability in ART concentrations and related toxicity or treatment outcome. Despite the negative perception of genetic research among the general public, this type of investigation is now widely accepted by concerned parties: patients, relatives, and study volunteers.
Anti-HIV Agents/pharmacokinetics, Continental Population Groups, Ethnic Groups, Female, Genetic Variation, Humans, Male, Sex Characteristics
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