Inflammasomes: mechanism of assembly, regulation and signalling.

Details

Serval ID
serval:BIB_0EE04AC88A5C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Inflammasomes: mechanism of assembly, regulation and signalling.
Journal
Nature reviews. Immunology
Author(s)
Broz P., Dixit V.M.
ISSN
1474-1741 (Electronic)
ISSN-L
1474-1733
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
16
Number
7
Pages
407-420
Language
english
Abstract
Inflammasomes are multiprotein signalling platforms that control the inflammatory response and coordinate antimicrobial host defences. They are assembled by pattern-recognition receptors following the detection of pathogenic microorganisms and danger signals in the cytosol of host cells, and they activate inflammatory caspases to produce cytokines and to induce pyroptotic cell death. The clinical importance of inflammasomes reaches beyond infectious disease, as dysregulated inflammasome activity is associated with numerous hereditary and acquired inflammatory disorders. In this Review, we discuss the recent developments in inflammasome research with a focus on the molecular mechanisms that govern inflammasome assembly, signalling and regulation.

Keywords
Animals, Humans, Inflammasomes/physiology, Signal Transduction/immunology
Pubmed
Web of science
Create date
25/10/2017 10:05
Last modification date
20/08/2019 12:35
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