Crosstalk between xenobiotics metabolism and circadian clock.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_0EB10E2D7D72
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Crosstalk between xenobiotics metabolism and circadian clock.
Journal
FEBS Letters
Author(s)
Claudel T., Cretenet G., Saumet A., Gachon F.
ISSN
0014-5793
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
581
Number
19
Pages
3626-3633
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Abstract
Many aspects of physiology and behavior in organisms from bacteria to man are subjected to circadian regulation. Indeed, the major function of the circadian clock consists in the adaptation of physiology to daily environmental change and the accompanying stresses such as exposition to UV-light and food-contained toxic compounds. In this way, most aspects of xenobiotic detoxification are subjected to circadian regulation. These phenomena are now considered as the molecular basis for the time-dependence of drug toxicities and efficacy. However, there is now evidences that these toxic compounds can, in turn, regulate circadian gene expression and thus influence circadian rhythms. As food seems to be the major regulator of peripheral clock, the possibility that food-contained toxic compounds participate in the entrainment of the clock will be discussed.
Keywords
Aging, Animals, Biological Clocks/drug effects, Biological Clocks/genetics, Circadian Rhythm/drug effects, Circadian Rhythm/genetics, Food/toxicity, Gene Expression/drug effects, Gene Expression Regulation, Humans, Mice, Transcription Factors/metabolism, Xenobiotics/metabolism, Xenobiotics/toxicity
Pubmed
Web of science
Open Access
Yes
Create date
01/10/2009 14:13
Last modification date
11/12/2019 7:08
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