Crosstalk between xenobiotics metabolism and circadian clock.

Détails

Ressource 1Demande d'une copie Sous embargo indéterminé.
Etat: Public
Version: Final published version
ID Serval
serval:BIB_0EB10E2D7D72
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Crosstalk between xenobiotics metabolism and circadian clock.
Périodique
FEBS Letters
Auteur(s)
Claudel T., Cretenet G., Saumet A., Gachon F.
ISSN
0014-5793
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
581
Numéro
19
Pages
3626-3633
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Résumé
Many aspects of physiology and behavior in organisms from bacteria to man are subjected to circadian regulation. Indeed, the major function of the circadian clock consists in the adaptation of physiology to daily environmental change and the accompanying stresses such as exposition to UV-light and food-contained toxic compounds. In this way, most aspects of xenobiotic detoxification are subjected to circadian regulation. These phenomena are now considered as the molecular basis for the time-dependence of drug toxicities and efficacy. However, there is now evidences that these toxic compounds can, in turn, regulate circadian gene expression and thus influence circadian rhythms. As food seems to be the major regulator of peripheral clock, the possibility that food-contained toxic compounds participate in the entrainment of the clock will be discussed.
Mots-clé
Aging, Animals, Biological Clocks/drug effects, Biological Clocks/genetics, Circadian Rhythm/drug effects, Circadian Rhythm/genetics, Food/toxicity, Gene Expression/drug effects, Gene Expression Regulation, Humans, Mice, Transcription Factors/metabolism, Xenobiotics/metabolism, Xenobiotics/toxicity
Pubmed
Web of science
Open Access
Oui
Création de la notice
01/10/2009 15:13
Dernière modification de la notice
11/12/2019 8:08
Données d'usage