Functional interplay within the epitranscriptome: Reality or fiction?

Details

Serval ID
serval:BIB_0E71F94EA691
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Functional interplay within the epitranscriptome: Reality or fiction?
Journal
BioEssays
Author(s)
Worpenberg L., Paolantoni C., Roignant J.Y.
ISSN
1521-1878 (Electronic)
ISSN-L
0265-9247
Publication state
Published
Issued date
02/2022
Peer-reviewed
Oui
Volume
44
Number
2
Pages
e2100174
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
RNA modifications have recently emerged as an important regulatory layer of gene expression. The most prevalent and reversible modification on messenger RNA (mRNA), N6-methyladenosine, regulates most steps of RNA metabolism and its dysregulation has been associated with numerous diseases. Other modifications such as 5-methylcytosine and N1-methyladenosine have also been detected on mRNA but their abundance is lower and still debated. Adenosine to inosine RNA editing is widespread on coding and non-coding RNA and can alter mRNA decoding as well as protect against autoimmune diseases. 2'-O-methylation of the ribose and pseudouridine are widespread on ribosomal and transfer RNA and contribute to proper RNA folding and stability. While the understanding of the individual role of RNA modifications has now reached an unprecedented stage, still little is known about their interplay in the control of gene expression. In this review we discuss the examples where such interplay has been observed and speculate that with the progress of mapping technologies more of those will rapidly accumulate.
Keywords
5-Methylcytosine, Adenosine/metabolism, RNA/metabolism, RNA Processing, Post-Transcriptional, RNA, Messenger/metabolism, 2′-O-methylation, RNA modifications, epitranscriptomics, inosine, m5C, m6A, pseudouridine
Pubmed
Web of science
Open Access
Yes
Create date
11/12/2021 1:44
Last modification date
01/02/2022 7:34
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