Is the coiled body involved in nucleolar functions?

Details

Serval ID
serval:BIB_0DCF85BE7754
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Is the coiled body involved in nucleolar functions?
Journal
Experimental Cell Research
Author(s)
Malatesta M., Zancanaro C., Martin T.E., Chan E.K., Amalric F., Lührmann R., Vogel P., Fakan S.
ISSN
0014-4827 (Print)
ISSN-L
0014-4827
Publication state
Published
Issued date
1994
Volume
211
Number
2
Pages
415-419
Language
english
Abstract
Coiled bodies (CBs) are structural constituents observed in nuclei of most eukaryotic cells. They usually occur in the nucleoplasm as well as in contact with the nucleolar surface. In this work we studied the hepatocyte nuclei of hibernating dormice in order to investigate possible modifications of CBs along the seasonal cycle. CBs were abundant during hibernation and rapidly disappeared upon arousal from hibernation. Moreover, CBs were frequently found to be integrated into the nucleolar body. Immunocytochemical analyses showed that CBs contain nucleoplasmic as well as nucleolar RNA-processing factors, suggesting an "ambiguous" role for this organelle in the nuclear functions.
Keywords
Animals, Antibodies, Monoclonal, Cell Nucleolus/metabolism, Cell Nucleolus/ultrastructure, Chromosomal Proteins, Non-Histone/metabolism, Hibernation, Liver/metabolism, Liver/ultrastructure, Microscopy, Immunoelectron, Nuclear Proteins/immunology, Nuclear Proteins/metabolism, RNA Precursors/metabolism, Ribonucleoproteins, Small Nuclear/metabolism, Rodentia
Pubmed
Web of science
Create date
24/01/2008 18:32
Last modification date
20/08/2019 13:34
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