Prevalence and clinical importance of mesenteric venous thrombosis in the Swiss Inflammatory Bowel Disease Cohort
Details
Serval ID
serval:BIB_0DBF24CC0B2A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prevalence and clinical importance of mesenteric venous thrombosis in the Swiss Inflammatory Bowel Disease Cohort
Journal
Ajr. American Journal of Roentgenology
Working group(s)
Swiss Inflammatory Bowel Disease Cohort Study Group
Contributor(s)
Bauerfeind P., Beglinger C., Begré S., Bengoa J., Binek J., Boller D., Borovicka J., Braegger C., Burnand B., Camara R., Criblez D., Degen L., Delarive J., de Saussure P., Ehmann T., El Wafa A., Engelmann M., Felley C., Frei A., Frei R., Fried M., Friedt M., Froehlich F., Gallot-Lavallée S., Gerlach T., Geyer M., Girardin M., Goetze O., Haack H., Hediger S., Hengstler P., Heyland K., Janiak P., Juillerat P., Kessler Brondolo V., Knoblauch C., Kullak-Ublick GA., Maillard M., Manz M., Meier R., Meyenberger C., Michetti P., Mottet C., Müller C., Müllhaupt B., Nicolet T., Nydegger A., Pache I., Piccoli F., Pilz J., Pittet V., Rentsch R., Rey JP., Rihs S., Rogler D., Rogler G., Sagmeister M., Sauter B., Schaub N., Schibli S., Schoepfer AM., Seibold F., Spalinger J., Stadler P., Steuerwald M., Straumann A., Sulz M., Tempia-Caliera M., Thorens£££Joël£££ J. , Vader JP., Vavricka SR., Vögtlin J., Von Känel R., Wachter G., Wermuth J., Wiesel P.
ISSN
1546-3141 (Electronic)
ISSN-L
0361-803X
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
203
Number
1
Pages
62-69
Language
english
Abstract
OBJECTIVE: The purpose of this study was to evaluate the prevalence of mesenteric venous thrombosis (MVT) in the Swiss Inflammatory Bowel Disease Cohort Study and to correlate MVT with clinical outcome.
MATERIALS AND METHODS: Abdominal portal phase CT was used to examine patients with inflammatory bowel disease (IBD). Two experienced abdominal radiologists retrospectively analyzed the images, focusing on the superior and inferior mesenteric vein branches and looking for signs of acute or chronic thrombosis. The location of abnormalities was registered. The presence of MVT was correlated with IBD-related radiologic signs and complications.
RESULTS: The cases of 160 patients with IBD (89 women, 71 men; Crohn disease [CD], 121 patients; ulcerative colitis [UC], 39 patients; median age at diagnosis, 27 years for patients with CD, 32 years for patients with UC) were analyzed. MVT was detected in 43 patients with IBD (26.8%). One of these patients had acute MVT; 38, chronic MVT; and four, both. The prevalence of MVT did not differ between CD (35/121 [28.9%]) and UC (8/39 [20.5%]) (p = 0.303). The location of thrombosis was different between CD and UC (CD, jejunal or ileal veins only [p = 0.005]; UC, rectocolic veins only [p = 0.001]). Almost all (41/43) cases of thrombosis were peripheral. MVT in CD patients was more frequently associated with bowel wall thickening (p = 0.013), mesenteric fat hypertrophy (p = 0.005), ascites (p = 0.002), and mesenteric lymph node enlargement (p = 0.036) and was associated with higher rate of bowel stenosis (p < 0.001) and more intestinal IBD-related surgery (p = 0.016) in the outcome. Statistical analyses for patients with UC were not relevant because of the limited population (n = 8).
CONCLUSION: MVT is frequently found in patients with IBD. Among patients with CD, MVT is associated with bowel stenosis and CD-related intestinal surgery.
MATERIALS AND METHODS: Abdominal portal phase CT was used to examine patients with inflammatory bowel disease (IBD). Two experienced abdominal radiologists retrospectively analyzed the images, focusing on the superior and inferior mesenteric vein branches and looking for signs of acute or chronic thrombosis. The location of abnormalities was registered. The presence of MVT was correlated with IBD-related radiologic signs and complications.
RESULTS: The cases of 160 patients with IBD (89 women, 71 men; Crohn disease [CD], 121 patients; ulcerative colitis [UC], 39 patients; median age at diagnosis, 27 years for patients with CD, 32 years for patients with UC) were analyzed. MVT was detected in 43 patients with IBD (26.8%). One of these patients had acute MVT; 38, chronic MVT; and four, both. The prevalence of MVT did not differ between CD (35/121 [28.9%]) and UC (8/39 [20.5%]) (p = 0.303). The location of thrombosis was different between CD and UC (CD, jejunal or ileal veins only [p = 0.005]; UC, rectocolic veins only [p = 0.001]). Almost all (41/43) cases of thrombosis were peripheral. MVT in CD patients was more frequently associated with bowel wall thickening (p = 0.013), mesenteric fat hypertrophy (p = 0.005), ascites (p = 0.002), and mesenteric lymph node enlargement (p = 0.036) and was associated with higher rate of bowel stenosis (p < 0.001) and more intestinal IBD-related surgery (p = 0.016) in the outcome. Statistical analyses for patients with UC were not relevant because of the limited population (n = 8).
CONCLUSION: MVT is frequently found in patients with IBD. Among patients with CD, MVT is associated with bowel stenosis and CD-related intestinal surgery.
Keywords
Adult, Contrast Media/diagnostic use, Female, Humans, Inflammatory Bowel Diseases/complications, Male, Mesenteric Veins, Prevalence, Retrospective Studies, Switzerland/epidemiology, Tomography, X-Ray Computed/methods, Venous Thrombosis/epidemiology, Venous Thrombosis/etiology
Pubmed
Web of science
Create date
22/11/2014 9:54
Last modification date
20/08/2019 12:34
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