Improved susceptibility-weighted imaging for high contrast and resolution thalamic nuclei mapping at 7T.

Details

Serval ID
serval:BIB_0D315EB8ED5C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Improved susceptibility-weighted imaging for high contrast and resolution thalamic nuclei mapping at 7T.
Journal
Magnetic resonance in medicine
Author(s)
Jorge J., Gretsch F., Najdenovska E., Tuleasca C., Levivier M., Maeder P., Gallichan D., Marques J.P., Bach Cuadra M.
ISSN
1522-2594 (Electronic)
ISSN-L
0740-3194
Publication state
Published
Issued date
09/2020
Peer-reviewed
Oui
Volume
84
Number
3
Pages
1218-1234
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The thalamus is an important brain structure and neurosurgical target, but its constituting nuclei are challenging to image non-invasively. Recently, susceptibility-weighted imaging (SWI) at ultra-high field has shown promising capabilities for thalamic nuclei mapping. In this work, several methodological improvements were explored to enhance SWI quality and contrast, and specifically its ability for thalamic imaging.
High-resolution SWI was performed at 7T in healthy participants, and the following techniques were applied: (a) monitoring and retrospective correction of head motion and B <sub>0</sub> perturbations using integrated MR navigators, (b) segmentation and removal of venous vessels on the SWI data using vessel enhancement filtering, and (c) contrast enhancement by tuning the parameters of the SWI phase-magnitude combination. The resulting improvements were evaluated with quantitative metrics of image quality, and by comparison to anatomo-histological thalamic atlases.
Even with sub-millimeter motion and natural breathing, motion and field correction produced clear improvements in both magnitude and phase data quality (76% and 41%, respectively). The improvements were stronger in cases of larger motion/field deviations, mitigating the dependence of image quality on subject performance. Optimizing the SWI phase-magnitude combination yielded substantial improvements in image contrast, particularly in the thalamus, well beyond previously reported SWI results. The atlas comparisons provided compelling evidence of anatomical correspondence between SWI features and several thalamic nuclei, for example, the ventral intermediate nucleus. Vein detection performed favorably inside the thalamus, and vein removal further improved visualization.
Altogether, the proposed developments substantially improve high-resolution SWI, particularly for thalamic nuclei imaging.
Keywords
field tracking, motion correction, susceptibility-weighted imaging, thalamic nuclei, vein segmentation
Pubmed
Web of science
Funding(s)
University of Lausanne / CRND-31188
Create date
17/02/2020 16:56
Last modification date
02/09/2020 5:22
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