Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution
Details
Serval ID
serval:BIB_0D20366C5661
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution
Journal
Journal of Experimental Medicine
ISSN
0022-1007 (Print)
Publication state
Published
Issued date
12/1991
Volume
174
Number
6
Pages
1657-60
Notes
Journal Article --- Old month value: Dec 1
Abstract
We have previously found that a Tyr residue was critical for the interaction of peptides with the Kd molecule, and therefore may be acting as an anchor residue. In the present report we show that it is possible to convert a self peptide sequence into a Kd-restricted neo-antigen by a single Tyr substitution at position 2 of the peptide. This supports the idea that Tyr is a critical element in the binding motif of Kd-restricted peptides and is a finding that could also prove useful for vaccine development.
Keywords
Amino Acid Sequence
Animals
H-2 Antigens/*immunology
Immunization
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Molecular Sequence Data
Peptides/*immunology
Structure-Activity Relationship
T-Lymphocytes, Cytotoxic/immunology
Tyrosine
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 12:27
Last modification date
20/08/2019 13:34