Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression.

Details

Serval ID
serval:BIB_0CD1A282E7A5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression.
Journal
Faseb Journal
Author(s)
Wahli W., Martinez E.
ISSN
0892-6638[print], 0892-6638[linking]
Publication state
Published
Issued date
06/1991
Volume
5
Number
9
Pages
2243-2249
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The nuclear hormone receptor superfamily is characterized by an impressive functional diversity of its members despite a remarkable overall structural unity. A variety of ligands bind specifically to them and these receptors control gene networks that have profound effects on growth, development, and homeostasis. The ligand-receptor complexes recognize transcriptional enhancer DNA sequences, the hormone response elements, resulting in induction or repression of gene activity. The similarity between all these hormone response enhancer elements, as well as between the receptors themselves, indicates a conserved general strategy for the hormonal control of transcription by steroids. The activated receptors bind to responsive promoters and most likely mediate the assembly of stage- and tissue-specific transcription factor complexes that stimulate or inhibit gene expression.
Keywords
Animals, Base Sequence, Gene Expression Regulation, Molecular Sequence Data, Multigene Family, Receptors, Steroid/genetics
Pubmed
Web of science
Create date
24/01/2008 17:04
Last modification date
20/08/2019 13:34
Usage data