Lack of deleterious effect of slow-release sodium fluoride treatment on cortical bone histology and quality in osteoporotic patients
Details
Serval ID
serval:BIB_0CBCAD328F2F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Lack of deleterious effect of slow-release sodium fluoride treatment on cortical bone histology and quality in osteoporotic patients
Journal
Bone and Mineral
ISSN
0169-6009
Publication state
Published
Issued date
07/1992
Volume
18
Number
1
Pages
65-76
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jul
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jul
Abstract
We evaluated the effects of intermittent slow-release sodium fluoride (SRNaF) and continuous calcium citrate therapy on cortical bone histology, reflection ultrasound velocity (material strength) and back-scattered electron image analysis (BEI) in 26 osteoporotic patients before and following therapy. All measurements were made on transiliac crest bone biopsies obtained before and following 2 years of therapy in each patient. For all 26 patients there were no significant changes in cortical bone histomorphometric parameters. In 15 patients in whom bone material quality was assessed by reflection ultrasound, there was no change in velocity (4000 +/- 227 SD to 4013 +/- 240 m/s). BEI disclosed no mineralization defects or the presence of woven bone. Mean atomic number (density) of bone increased slightly, but significantly (9.261 +/- 0.311 to 9.457 +/- 0.223, P = 0.031). While these changes are less marked than those observed for cancellous bone, they indicate that this form of therapy does not adversely affect cortical bone remodelling.
Keywords
Adult
Aged
Bone Density/drug effects
Bone Remodeling/*drug effects
Citrates/administration & dosage/*therapeutic use
Citric Acid
Delayed-Action Preparations
Drug Therapy, Combination
Female
Humans
Male
Middle Aged
Osteoporosis/*drug therapy/pathology/physiopathology
Osteoporosis, Postmenopausal/drug therapy/pathology/physiopathology
Sodium Fluoride/administration & dosage/*therapeutic use
Spinal Fractures
Pubmed
Web of science
Create date
29/01/2008 17:38
Last modification date
20/08/2019 13:34