Dynamin-SNARE interactions control trans-SNARE formation in intracellular membrane fusion.

Details

Serval ID
serval:BIB_0AD97B84FD64
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dynamin-SNARE interactions control trans-SNARE formation in intracellular membrane fusion.
Journal
Nature Communications
Author(s)
Alpadi K., Kulkarni A., Namjoshi S., Srinivasan S., Sippel K.H., Ayscough K., Zieger M., Schmidt A., Mayer A., Evangelista M., Quiocho F.A., Peters C.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
2013
Volume
4
Pages
1704
Language
english
Abstract
The fundamental processes of membrane fission and fusion determine size and copy numbers of intracellular organelles. Although SNARE proteins and tethering complexes mediate intracellular membrane fusion, fission requires the presence of dynamin or dynamin-related proteins. Here we study these reactions in native yeast vacuoles and find that the yeast dynamin homologue Vps1 is not only an essential part of the fission machinery, but also controls membrane fusion by generating an active Qa SNARE-tethering complex pool, which is essential for trans-SNARE formation. Our findings provide new insight into the role of dynamins in membrane fusion by directly acting on SNARE proteins.
Pubmed
Web of science
Open Access
Yes
Create date
01/07/2013 9:11
Last modification date
20/08/2019 13:32
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