Punishment-Predictive Cues Guide Avoidance through Potentiation of Hypothalamus-to-Habenula Synapses.

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Serval ID
serval:BIB_080285A21A74
Type
Article: article from journal or magazin.
Collection
Publications
Title
Punishment-Predictive Cues Guide Avoidance through Potentiation of Hypothalamus-to-Habenula Synapses.
Journal
Neuron
Author(s)
Trusel M., Nuno-Perez A., Lecca S., Harada H., Lalive A.L., Congiu M., Takemoto K., Takahashi T., Ferraguti F., Mameli M.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
102
Number
1
Pages
120-127.e4
Language
english
Abstract
Throughout life, individuals learn to predict a punishment via its association with sensory stimuli. This process ultimately prompts goal-directed actions to prevent the danger, a behavior defined as avoidance. Neurons in the lateral habenula (LHb) respond to aversive events as well as to environmental cues predicting them, supporting LHb contribution to cue-punishment association. However, whether synaptic adaptations at discrete habenular circuits underlie such associative learning to instruct avoidance remains elusive. Here, we find that, in mice, contingent association of an auditory cue (tone) with a punishment (foot shock) progressively causes cue-driven LHb neuronal excitation during avoidance learning. This process is concomitant with the strengthening of LHb AMPA receptor-mediated neurotransmission. Such a phenomenon occludes long-term potentiation and occurs specifically at hypothalamus-to-habenula synapses. Silencing hypothalamic-to-habenulainputs or optically inactivating postsynaptic AMPA receptors within the LHb disrupts avoidance learning. Altogether, synaptic strengthening at a discrete habenular circuit transforms neutral stimuli into salient punishment-predictive cues to guide avoidance.
Keywords
AMPA receptors, avoidance, lateral habenula, long-term potentiation
Pubmed
Web of science
Create date
31/03/2019 15:31
Last modification date
20/08/2019 13:30
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