FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded

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Serval ID
serval:BIB_072223A553B5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded
Journal
Bioinformatics
Author(s)
Prilusky  J., Felder  C. E., Zeev-Ben-Mordehai  T., Rydberg  E. H., Man  O., Beckmann  J. S., Silman  I., Sussman  J. L.
ISSN
1367-4803 (Print)
Publication state
Published
Issued date
08/2005
Volume
21
Number
16
Pages
3435-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug 15
Abstract
An easy-to-use, versatile and freely available graphic web server, FoldIndex is described: it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of Uversky and co-workers, which is based on the average residue hydrophobicity and net charge of the sequence. FoldIndex has an error rate comparable to that of more sophisticated fold prediction methods. Sliding windows permit identification of large regions within a protein that possess folding propensities different from those of the whole protein.
Keywords
*Algorithms Computer Graphics Computer Simulation Energy Transfer Internet *Models, Chemical *Models, Molecular Protein Conformation Protein Folding Proteins/analysis/*chemistry Sequence Alignment/*methods Sequence Analysis, Protein/*methods *Software Structure-Activity Relationship *User-Computer Interface
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 17:17
Last modification date
25/09/2019 7:08
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