Temporal and spatial appearance of the membrane cytoskeleton and perineuronal nets in the rat neocortex.

Details

Serval ID
serval:BIB_071D79B91BB8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Temporal and spatial appearance of the membrane cytoskeleton and perineuronal nets in the rat neocortex.
Journal
Neuroscience Letters
Author(s)
Wintergerst E.S., Vogt Weisenhorn D.M., Rathjen F.G., Riederer B.M., Lambert S., Celio M.R.
ISSN
0304-3940 (Print)
ISSN-L
0304-3940
Publication state
Published
Issued date
1996
Volume
209
Number
3
Pages
173-176
Language
english
Abstract
Parvalbumin-immunoreactive interneurons are surrounded by perineuronal nets, containing molecules of the extracellular matrix (e.g. tenascin-R). Furthermore, they seem to have a special cytoskeleton composed of, among others, ankyrinR and beta Rspectrin. In the present developmental study we showed that the intracellular markers parvalbumin, ankyrinR and beta Rspectrin as well as Vicia Villosa agglutinin, an extracellular marker for perineuronal nets, appeared in the second postnatal week. In the third postnatal week, ankyrinR and beta R spectrin were present in the parvalbumin-positive interneurons. Tenascin-R appeared in a similar topographic distribution as the intracellular markers. The adult pattern was established upon the end of the fourth postnatal week. Our results indicate that cytoskeletal maturity maybe a prerequisite for the organization of perineuronal nets of extracellular matrix.
Keywords
Animals, Cerebral Cortex/cytology, Cerebral Cortex/growth & development, Cytoskeletal Proteins/biosynthesis, Cytoskeleton/metabolism, Cytoskeleton/ultrastructure, Extracellular Matrix Proteins/biosynthesis, Female, Immunohistochemistry, Interneurons/physiology, Nerve Net/anatomy & histology, Nerve Net/growth & development, Rats, Rats, Inbred Strains, Tenascin/biosynthesis, Time Factors
Pubmed
Web of science
Create date
24/01/2008 14:34
Last modification date
20/08/2019 12:29
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