Article: article d'un périodique ou d'un magazine.
Temporal and spatial appearance of the membrane cytoskeleton and perineuronal nets in the rat neocortex.
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Parvalbumin-immunoreactive interneurons are surrounded by perineuronal nets, containing molecules of the extracellular matrix (e.g. tenascin-R). Furthermore, they seem to have a special cytoskeleton composed of, among others, ankyrinR and beta Rspectrin. In the present developmental study we showed that the intracellular markers parvalbumin, ankyrinR and beta Rspectrin as well as Vicia Villosa agglutinin, an extracellular marker for perineuronal nets, appeared in the second postnatal week. In the third postnatal week, ankyrinR and beta R spectrin were present in the parvalbumin-positive interneurons. Tenascin-R appeared in a similar topographic distribution as the intracellular markers. The adult pattern was established upon the end of the fourth postnatal week. Our results indicate that cytoskeletal maturity maybe a prerequisite for the organization of perineuronal nets of extracellular matrix.
Animals, Cerebral Cortex/cytology, Cerebral Cortex/growth & development, Cytoskeletal Proteins/biosynthesis, Cytoskeleton/metabolism, Cytoskeleton/ultrastructure, Extracellular Matrix Proteins/biosynthesis, Female, Immunohistochemistry, Interneurons/physiology, Nerve Net/anatomy & histology, Nerve Net/growth & development, Rats, Rats, Inbred Strains, Tenascin/biosynthesis, Time Factors
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