Vascular Abnormalities Detected with Chest CT in COVID-19: Spectrum, Association with Parenchymal Lesions, Cardiac Changes, and Correlation with Clinical Severity (COVID-CAVA Study).

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Ressource 1Download: diagnostics-11-00606.pdf (1229.64 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_066B4C4BB1E0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Vascular Abnormalities Detected with Chest CT in COVID-19: Spectrum, Association with Parenchymal Lesions, Cardiac Changes, and Correlation with Clinical Severity (COVID-CAVA Study).
Journal
Diagnostics
Author(s)
Qanadli S.D., Sauter A.W., Alkadhi H., Christe A., Poletti P.A., Ebner L., Rotzinger D.C.
ISSN
2075-4418 (Print)
ISSN-L
2075-4418
Publication state
Published
Issued date
29/03/2021
Peer-reviewed
Oui
Volume
11
Number
4
Pages
606
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Although vascular abnormalities are thought to affect coronavirus disease 2019 (COVID-19) patients' outcomes, they have not been thoroughly characterized in large series of unselected patients. The Swiss national registry coronavirus-associated vascular abnormalities (CAVA) is a multicentric cohort of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who underwent a clinically indicated chest computed tomography (CT) aiming to assess the prevalence, severity, distribution, and prognostic value of vascular and non-vascular-related CT findings. Clinical outcomes, stratified as outpatient treatment, inpatient without mechanical ventilation, inpatient with mechanical ventilation, or death, will be correlated with CT and biological markers. The main objective is to assess the prevalence of cardiovascular abnormalities-including pulmonary embolism (PE), cardiac morphology, and vascular congestion. Secondary objectives include the predictive value of cardiovascular abnormalities in terms of disease severity and fatal outcome and the association of lung inflammation with vascular abnormalities at the segmental level. New quantitative approaches derived from CT imaging are developed and evaluated in this study. Patients with and without vascular abnormalities will be compared, which is supposed to provide insights into the prognostic role and potential impact of such signs on treatment strategy. Results are expected to enable the development of an integrative score combining both clinical data and imaging findings to predict outcomes.
Keywords
COVID-19, computed tomography, perfusion, pulmonary embolism, respiratory failure, vascular congestion
Pubmed
Open Access
Yes
Create date
04/04/2021 9:29
Last modification date
14/04/2021 6:36
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