Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans

Details

Serval ID
serval:BIB_065A965BDAD4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans
Journal
Journal of Clinical Investigation
Author(s)
Vollenweider  P., Tappy  L., Randin  D., Schneiter  P., Jequier  E., Nicod  P., Scherrer  U.
ISSN
0021-9738 (Print)
Publication state
Published
Issued date
07/1993
Volume
92
Number
1
Pages
147-54
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Abstract
Euglycemic hyperinsulinemia evokes both sympathetic activation and vasodilation in skeletal muscle, but the mechanism remains unknown. To determine whether insulin per se or insulin-induced stimulation of carbohydrate metabolism is the main excitatory stimulus, we performed, in six healthy lean subjects, simultaneous microneurographic recordings of muscle sympathetic nerve activity, plethysmographic measurements of calf blood flow, and calorimetric determinations of carbohydrate oxidation rate. Measurements were made during 2 h of: (a) insulin/glucose infusion (hyperinsulinemic [6 pmol/kg per min] euglycemic clamp), (b) exogenous glucose infusion at a rate matched to that attained during protocol a, and (c) exogenous fructose infusion at the same rate as for glucose infusion in protocol b. For a comparable rise in carbohydrate oxidation, insulin/glucose infusion that resulted in twofold greater increases in plasma insulin concentrations than did glucose infusion alone, evoked twofold greater increases in both muscle sympathetic nerve activity and calf blood flow. Fructose infusion, which increased carbohydrate oxidation comparably, but had only a minor effect on insulinemia, did not stimulate either muscle sympathetic nerve activity or calf blood flow. These observations suggest that in humans hyperinsulinemia per se, rather than insulin-induced stimulation of carbohydrate metabolism, is the main mechanism that triggers both sympathetic activation and vasodilation in skeletal muscle.
Keywords
Adult Blood Glucose/metabolism Calorimetry *Carbohydrate Metabolism Catecholamines/blood Energy Metabolism Fructose/blood Humans Insulin/*blood Muscles/*blood supply Potassium/blood Regional Blood Flow Sympathetic Nervous System/*physiology Vascular Resistance
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 13:36
Last modification date
20/08/2019 12:28
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