The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles.

Details

Serval ID
serval:BIB_064DBD07026C
Type
Article: article from journal or magazin.
Collection
Publications
Title
The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles.
Journal
Science
Author(s)
Mueller C.A., Broz P., Müller S.A., Ringler P., Erne-Brand F., Sorg I., Kuhn M., Engel A., Cornelis G.R.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
310
Number
5748
Pages
674-676
Language
english
Abstract
Many pathogenic bacteria use injectisomes to deliver effector proteins into host cells through type III secretion. Injectisomes consist of a basal body embedded in the bacterial membranes and a needle. In Yersinia, translocation of effectors requires the YopB and YopD proteins, which form a pore in the target cell membrane, and the LcrV protein, which assists the assembly of the pore. Here we report that LcrV forms a distinct structure at the tip of the needle, the tip complex. This unique localization of LcrV may explain its crucial role in the translocation process and its efficacy as the main protective antigen against plague.

Keywords
Antigens, Bacterial/physiology, Antigens, Bacterial/ultrastructure, Bacterial Outer Membrane Proteins/physiology, Bacterial Outer Membrane Proteins/ultrastructure, Genetic Complementation Test, Microscopy, Electron, Scanning, Pore Forming Cytotoxic Proteins, Yersinia enterocolitica/physiology, Yersinia enterocolitica/ultrastructure
Pubmed
Web of science
Create date
25/10/2017 10:05
Last modification date
20/08/2019 12:28
Usage data