A proven case of materno-foetal transfusion determined by cytogenetic and DNA analysis

Details

Serval ID
serval:BIB_05CD8EC3983A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A proven case of materno-foetal transfusion determined by cytogenetic and DNA analysis
Journal
Clinical Genetics
Author(s)
Paoloni-Giacobino  A., Dutoit  M. H., Morris  M. A., Dahoun  S. P.
ISSN
0009-9163 (Print)
Publication state
Published
Issued date
04/1999
Volume
55
Number
4
Pages
256-8
Notes
Case Reports
Journal Article --- Old month value: Apr
Abstract
We report a case of materno-foetal transfusion in a phenotypically normal male foetus after death in utero at the 35th week of gestation. We have used cytogenetic and polymerase chain reaction (PCR) microsatellite analysis to determine the presence of maternal cells in foetal blood collected by intracardiac puncture. In the intracardiac blood sample, maternal cells were estimated to comprise between 5 and 10% of nucleated foetal blood cells. When there is a suspicion of foetal genetic pathology, it is necessary to be aware that the foetal blood karyotype may be misrepresentative, as the analysed blood cells can indeed be of maternal origin.
Keywords
Adult Female *Fetal Death Fetomaternal Transfusion/*diagnosis/mortality Humans Karyotyping Male Microsatellite Repeats Polymerase Chain Reaction Polymorphism, Genetic Pregnancy
Pubmed
Web of science
Create date
28/01/2008 12:14
Last modification date
20/08/2019 12:27
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