Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion.

Details

Serval ID
serval:BIB_05357332B60D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion.
Journal
The Journal of investigative dermatology
Author(s)
Sardella C., Winkler C., Quignodon L., Hardman J.A., Toffoli B., Giordano Attianese GMP, Hundt J.E., Michalik L., Vinson C.R., Paus R., Desvergne B., Gilardi F.
ISSN
1523-1747 (Electronic)
ISSN-L
0022-202X
Publication state
Published
Issued date
03/2018
Peer-reviewed
Oui
Volume
138
Number
3
Pages
500-510
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
PPARγ regulates multiple aspects of skin physiology, including sebocyte differentiation, keratinocyte proliferation, epithelial stem cell survival, adipocyte biology, and inflammatory skin responses. However, the effects of its global deletion, namely of nonredundant key functions of PPARγ signaling in mammalian skin, are yet unknown because of embryonic lethality. Here, we describe the skin and hair phenotype of a whole-body PPARγ-null mouse (Pparg <sup>Δ/Δ</sup> ), obtained by preserving PPARγ expression in the placenta. Pparg <sup>Δ/Δ</sup> mice exhibited total lipoatrophy and complete absence of sebaceous glands. Right after birth, hair follicle (HF) morphogenesis was transiently delayed, along with reduced expression of HF differentiation markers and of transcriptional regulators necessary for HF development. Later, adult Pparg <sup>Δ/Δ</sup> mice developed scarring alopecia and severe perifollicular inflammation. Skin analyses in other models of lipodystrophy, AZIP <sup>tg/+</sup> and Adipoq-Cre <sup>tg/+</sup> Pparg <sup>fl/fl</sup> mice, coupled with skin graft experiments, showed that the early defects observed in hair morphogenesis were caused by the absence of adipose tissue. In contrast, the late alteration of HF cycle and appearance of inflammation were observed only in Pparg <sup>Δ/Δ</sup> mice and likely were due to the lack sebaceous glands. Our findings underscore the increasing appreciation for the importance of adipose tissue-mediated signals in HF development and function.
Keywords
Animals, Cell Differentiation, Disease Models, Animal, Hair Follicle/growth & development, Homeostasis, Lipodystrophy/pathology, Mice, Mice, Knockout, Morphogenesis, PPAR gamma/genetics, PPAR gamma/physiology
Pubmed
Web of science
Create date
09/10/2017 16:16
Last modification date
20/08/2019 13:27
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